研究業績

2024年

学術論文

• "Identification of the Active EPA/AA-Binding Ether-Type Phosphatidylcholine Derived from the Starfish Patiria pectinifera for C2C12 Myotube Growth"
  A. Fukushima, K. Imamura, N. Takatani, M. Hosokawa, F. Beppu.
  ACS Omega in press (2024).

  • DOI: 10.1021/acsomega.4c07865
• "Dietary 7,10-dihydroxy-8(E)-octadecenoic acid reduces fat accumulation and prevents hyperglycemia and hyperlipidemia in diabetic/obese KK-Ay mice"
  F. Beppu, S. Fuji, H-R. Kim, C.T. Hou, K. Miyashita, M. Hosokawa.
  Biocatal. Agric. Biotechnol. 61, 103390 (2024).

  • DOI: 10.1016/j.bcab.2024.103390
• "Apo-12'-capsorubinal exhibits anti-inflammatory effects and activates nuclear factor erythroid 2-related factor 2 in RAW264.7 macrophages"
  N. Takatani, H. Miyafusa, Y. Yamano, F. Beppu, M. Hosokawa.
  Arch. Biochem. Biophys. 760, 110125 (2024).

  • DOI: 10.1016/j.abb.2024.110125
• "Identification of a novel monocyclic carotenoid and prediction of its biosynthetic genes in Algoriphagus sp. oki45"
  N. Takatani, T. Maoka, T. Sawabe, F. Beppu, M. Hosokawa
  Appl. Microbiol. Biotechnol. 108, 1-10 (2024).

  • DOI: 10.1007/s00253-023-12995-2

学会発表

• "水産物由来エーテル型脂質の健康機能性"
  別府史章.
  第6回脂質駆動学術産業創生研究部会講演会 (2024).
• "Fucoxanthinによる樹状細胞の炎症抑制およびミトコンドリア制御"
  七戸優斗・高谷直己・別府史章・細川雅史.
  令和6年度日本水産学会大会秋季大会 (2024).
• "Algoriphagus 属細菌におけるカロテノイド生合成系と抗炎症活性の解析"
  高谷直己・眞岡孝至・別府史章・細川雅史.
  第36回カロテノイド研究談話会 (2024).
• "フコキサンチン代謝物のミクログリアに対する抗炎症およびミトコンドリア機能制御作用"
  太田裕佑・別府史章・細川雅史・高谷直己.
  第62回日本油化学会年会 (2024).
• "フコキサンチン代謝物の細胞内局在とインフラマソーム活性化制御"
  赤澤凜香・河野友香・向村奏・高谷直己・別府史章・細川雅史.
  第62回日本油化学会年会 (2024).
• "マウス筋損傷モデルを用いたエーテル型脂質の筋形成制御作用の検討"
  今村響介・高谷直己・細川雅史・別府史章.
  第62回日本油化学会年会 (2024).
• "マクロファージに対するアポ-12’-カプソルビナールの炎症抑制およびNrf2活性化効果"
  高谷直己・宮房拓生・山野由美子・別府史章・細川雅史.
  第78回日本栄養・食糧学会大会 (2024).
• "褐藻フコキサンチンの高齢マウスにおける食餌誘導性肥満に与える影響"
  川添朱鞠・高谷直己・別府史章・細川雅史.
  第78回日本栄養・食糧学会大会 (2024).
• "北太平洋に分布する動物プランクトン群集の脂質特性分析"
  笹川拓真・山口篤・高谷直己・細川雅史・別府史章.
  令和6年度日本水産学会大会春季大会 (2024).
• "海洋細菌が産生する希少カロテノイドの同定と抗炎症活性評価"
  高谷直己・別府史章・細川雅史.
  令和6年度日本水産学会大会春季大会 (2024).

総説・著書

• "褐藻フコキサンチンの非アルコール性脂肪肝炎予防効果と生体利用率の向上（第19章）"
  細川雅史・高谷直己.
  カロテノイドの科学-基礎,研究の新展開,生理活性-（シーエムシー出版）, 201-208 (2024).
• "アポカロテノイドの動物細胞への生理活性（第22章）"
  高谷直己・細川雅史.
  カロテノイドの科学-基礎,研究の新展開,生理活性-（シーエムシー出版）, 228-235 (2024).

2023年

学術論文

• "Identification and tissue distribution of fucoxanthinol and amarouciaxanthin A fatty acid esters in fucoxanthin-fed mice"
  N. Takatani, K. Sakimura, K. Nagata, F. Beppu, Y. Yamano, T. Maoka, M. Hosokawa
  Food Chem. 410, 135318 (2023).

  • DOI: 10.1016/j.foodchem.2022.135318

学会発表

• "酵素的変換反応により合成したホスファチジルパンテノールの表皮角化細胞における抗炎症機能評価"
  音村茉佑・細川雅史・別府史章.
  第5回脂質駆動学術産業創生研究部会講演会 (2023).
• "アスタキサンチン由来アポカロテノイドの調製と生理活性評価"
  高谷直己・別府史章・山野由美子・眞岡孝至・細川雅史.
  第35回カロテノイド研究談話会 (2023).
• "Health promoting functions of the marine carotenoid fucoxanthin"
  Masashi Hosokawa.
  The 17th International Symposium on Biocatalysis and Agricultural Biotechnology (2023).
• "フコキサンチンの非アルコール性脂肪肝炎モデルマウスに対する予防機構"
  池田詩歩・高谷直己・別府史章・細川雅史.
  第9回北大・部局横断シンポジウム (2023).
• "フコキサンチン由来生体内開裂物の同定と活性化マクロファージおよび脂肪細胞に対する抗炎症作用"
  高谷直己・別府史章・細川雅史.
  第9回北大・部局横断シンポジウム (2023).
• "α-リノレン酸の細胞内変換を促進する食品成分の探索と制御機構の解明"
  小関万葉・高谷直己・別府史章・細川雅史.
  日本油化学会第61回年会 (2023).
• "フコキサンチンの非アルコール性脂肪性肝炎モデルマウスに対する予防機構"
  池田詩歩・高谷直己・別府史章・細川雅史.
  日本油化学会第61回年会 (2023).
• "海洋細菌が産生するn-3系多価不飽和脂肪酸含有脂質の生体内蓄積と糖・脂質代謝改善作用"
  佐藤花奈・別府史章・高谷直己・吉川典孝・相馬邦彦・池口主弥・細川雅史.
  日本油化学会第61回年会 (2023).
• "Fucoxanthinおよびその代謝物による樹状細胞の炎症制御作用"
  七戸優斗・高谷直己・別府史章・細川雅史.
  日本油化学会第61回年会 (2023).
• "C2C12筋芽細胞におけるアルキルグリセロールの筋管サイズ増大効果とリン脂質代謝調節作用"
  佐々木健朗・亀山美宇・高谷直己・細川雅史・別府史章.
  日本油化学会第61回年会 (2023).
• "海洋細菌Algoriphagus sp. oki45株が産生する新規カロテノイドの同定と生合成遺伝子の推定"
  高谷直己・土橋祐汰・澤辺智雄・眞岡孝至・別府史章・細川雅史.
  日本油化学会第61回年会 (2023).
• "Identification and tissue distribution of fucoxanthin-derived novel metabolites"
  Naoki Takatani, Kana Sakimura, Fumiaki Beppu, Yumiko Yamano, Takashi Maoka, Masashi Hosokawa.
  The 19th International Symposium on Carotenoids (2023).
• "Identification of novel and rare carotenoids from marine bacteria and their biosynthesis"
  Naoki Takatani.
  Taiwan-Japan International Symposium on Marine Science (2023).
• "未利用水産生物の可能性を拡げる脂質機能性研究"
  別府史章.
  第77回日本栄養・食糧学会大会 (2023).
• "Identification of novel monocyclic carotenoids in marine bacteria and their bioactivity"
  Masashi Hosokawa, Naoki Takatani, Fumiaki Beppu.
  2023 AOCS Annual Meeting & Expo (2023).
• " n-3PUFA 結合ホスファチジルグリセロールの細胞内脂肪酸調節機構の解明"
  富樫咲・別府史章・高谷直己・ 細川雅史.
  令和5年度日本水産学会大会春季大会 (2023).
• "海洋性カロテノイドastaxanthinの生体内代謝物の同定と組織分布"
  高谷直己・向村　奏・別府史章・細川雅史.
  令和5年度日本水産学会大会春季大会 (2023).

総説・著書

• "アポカロテノイドの同定と細胞機能調節作用に関する研究"
  高谷直己.
  一般財団法人 食品分析開発センターSUNATECメールマガジン (2023).
• "アポカロテノイドの細胞機能調節作用"
  高谷直己.
  アグリバイオ 7, 4, 338 (2023).

2022年

学術論文

• "Preparation of apoastaxanthinals and evaluation of their anti-inflammatory action against lipopolysaccharide-stimulated macrophages and adipocytes."
  N. Takatani, F. Beppu, Y. Yamano, T. Maoka, K. Miyashita, M. Hosokawa.
  ACS Omega 7, 22341 (2022).
• "Monocaprin enhances bioavailability of fucoxanthin in diabetic/obese KK-Ay Mice"
  K. Nagata, N. Takatani, F. Beppu, A. Abe, E. Tominaga, T. Fukuhara, M. Ozeki, M. Hosokawa.
  Mar. Drugs 20, 446 (2022).
• "ニンニク関連化合物のラジカル消去活性と魚油の酸化抑制効果"
  山谷祥史、細川雅史、宮下和夫
  日本食品科学工学会誌 69, 12, 549 (2022).
• "Dietary combination of fish oil and soy β-conglycinin inhibits fat accumulation and reduces blood glucose levels by altering gut microbiome composition in diabetic/obese KK-Ay mice"
  S. Wanezaki, T. Taniwaki, J. Miyamoto, M. Hosokawa.
  J. Oleo Sci. 72, 3, 303 (2022).
• "Reduction of serum lipid levels in diabetic obese KK‑Ay mice using monoalkyldiacylglycerol‑rich oil derived from Berryteuthis magister"
  M. Kakimoto, N. Takatani, M. Hosokawa, F. Beppu
  Fish. Sci. 89, 243-251 (2022).

2021年

学術論文

• "Identification of paracentrone in fucoxanthin-fed mice and anti-inflammatory effect against lipopolysaccharide-stimulated macrophages and adipocytes."
  N. Takatani, D. Taya, A. Katsuki, F. Beppu, T. Okitsu, Y. Yamano, A. Wada, K. Miyashita, M. Hosokawa.
  Mol. Nutr. Food Res. 65, 2000405 (2021).
• "Seco-type β-apocarotenoid generated by β-carotene oxidation exerts anti-inflammatory effect against activated macrophages."
  N. Takatani, F. Beppu, Y. Yamano, T. Maoka, M. Hosokawa.
  J. Oleo Sci. 70, 549 (2021).
• "Effects of fucoxanthin on the inhibition of dexamethasone-induced skeletal muscle loss in mice."
  M. Yoshikawa, M. Hosokawa, K. Miyashita, H. Nishino, T. Hashimoto.
  Nutrients 13, 1079 (2021).
• "n-3 Polyunsaturated fatty acids-enriched phosphatidylglycerol suppresses inflammation in LPS-stimulated RAW264.7 cells."
  L. Chen, N. Takatani, F. Beppu, K. Miyashita, M. Hosokawa.
  Fisheries Sci. 87, 727 (2021).

2020年

学術論文

• "Preparation of n-3 polyunsaturated phosphatidylglycerol from salmon roe lipids by phospholipase D and in vitro digestion."
  L. Chen, F. Beppu, K. Miyashita, M. Hosokawa.
  Eur. J. Lipid Sci. Technol. 122, 1900201 (2020).
• "Effect of Spirulina lipids on high-fat and high-sucrose diet induced obesity and hepatic lipid accumulation in C57BL/6J mice."
  YH. Yang, L. Du, M. Hosokawa, K. Miyashita.
  J. Funct. Foods 65, 103741 (2020).
• "Spirulina lipids alleviate oxidative stress and inflammation in mice fed a high-fat and high-sucrose diet."
  YH. Yang, L. Du, M. Hosokawa, K. Miyashita.
  Mar. Drugs 18, 148 (2020).
• "Effective extraction of carotenoids from brown seaweeds and vegetable leaves with edible oils."
  K. Teramukai, S. Kakui, F. Beppu, M. Hosokawa, K. Miyashita.
  Innov. Food Sci. Emerg. Technol. 60, 102302 (2020).
• "Ecogenomics of the marine benthic filamentous cyanobacterium Adonisia."
  J.M. Walter, F.H. Coutinho, L. Leomil, P.I. Hargreaves, M.E. Campe?o, V.V. Vieira, B.S. Silva, G.O. Fistarol, P.S. Salomon, T. Sawabe, S. Mino, M. Hosokawa, H. Miyashita, F. Maruyama, M.C. van Verk, B.E. Dutilh, C.C. Thompson, F.L. Thompson.
  Microb. Eco. 80, 249 (2020).
• "Fucoxanthinol attenuates oxidative stress?induced atrophy and loss in myotubes and reduces the triacylglycerol content in mature adipocytes."
  M. Yoshikawa, M. Hosokawa, K. Miyashita, T. Fujita, H. Nishino, T. Hashimoto.
  Mol. Biol. Rep. 47, 2703 (2020).
• "Preparation of phosphatidyl-panthenol by phospholipase D-mediated transphosphatidylation and its anti-inflammatory activity on macrophage-like RAW264.7 cells."
  Y. Yamamoto, K. Suzuri, T. Kunii, H. Kurihara, K. Miyashita, M. Hosokawa.
  Biocatal. Agric. Biotechnol. 26, 101629 (2020).
• "Fucoxanthin inhibits hepatic oxidative stress, inflammation, and fibrosis in diet-induced nonalcoholic steatohepatitis model mice."
  N. Takatani, Y. Kono, F. Beppu, Y. Okamatsu-Ogura, Y. Yamano, K. Miyashita, M. Hosokawa.
  Biochem. Biophys. Res. Commun. 528, 305 (2020).
• "Total lipids content, lipid class and fatty acid composition of ten species of microalgae."
  YH. Yang, L. Du, M. Hosokawa, K. Miyashita.
  J. Oleo Sci. 69, 1181 (2020).
• "Black chokeberry (Aronia melanocarpa) juice residue and its ethanol extract decrease serum lipid levels in high-fat diet-fed C57BL/6J mice."
  N. Mikami, Y. Hosotani, T. Saso, T. Ohta, K. Miyashita, M. Hosokawa.
  Int. J. Funct. Nutr. 1, 10 (2020).

総説・著書

• "海洋性カロテノイドの健康機能性に関する最近の動向"
  高谷直己・細川雅史.
  日本食品安全協会会誌 15, 78 (2020).
• "Nutraceutical characteristics of the brown seaweed carotenoid fucoxanthin."
  K. Miyashita, F. Beppu, M. Hosokawa, X. Liu, S. Wang.
  Arch. Biochem. Biophys. 686, 108364 (2020).
• "Bioactive significance of fucoxanthin and its effective extraction from brown seaweeds."
  K. Miyashita, F. Beppu, M. Hosokawa, X. Liu, S. Wang.
  Biocatal. Agric. Biotechnol. 26, 101639 (2020).
• "褐藻由来フコキサンチンの抗肥満効果"
  細川雅史.
  ファインケミカル 49, 22 (2020).
• "フコキサンチンによる非アルコール性脂肪肝炎抑制効果"
  高谷直己・細川雅史.
  生物工学会誌 98, 529 (2020).

2019年

学術論文

• "Phospholipase A2-mediated preparation of phosphatidylcholine containing ricinoleic acid and its anti-inflammatory effect on murine macrophage-like RAW264.7 cells."
  Y. Yamamoto, K. Harada, S. Kasuga, M. Hosokawa.
  Biocatal. Agric. Biotechnol. 21, 101141 (2019).
• "Variation in lipid components from 15 species of tropical and temperate seaweeds."
  E. Susanto, A. Suhaeli Fahmi, M. Hosokawa, K. Miyashita.
  Mar. Drugs 17, 630 (2019).
• "The Effect of n-3 PUFA binding phosphatidylglycerol on metabolic syndrome-related parameters and n-3 PUFA accretion in diabetic/obese KK-Ay mice."
  L. Chen, N. Takatani, F. Beppu, K. Miyashita, M. Hosokawa.
  Nutrients 11, 2866 (2019).

総説・著書

• "Furan fatty acids?a new approach."
  M. Miller, D. Romanazzi, M. Hosokawa, H. Uchida.
  Inform 30, 25 (2019).

2018年

学術論文

• "Detection and identification of furan fatty acids from fish lipids by high-performance liquid chromatography coupled to electrospray ionization quadrupole time-of-flight mass spectrometry"
  H. Uchida, Y. Itabashi, R. Watanabe, R. Matsushima, H. Oikawa, T. Suzuki, M. Hosokawa, N. Tsutsumi, K. Ura, D. Romanazzi, M.R. Miller.
  Food Chem. 252, 84 (2018).
• "Consumption of the edible sea urchin Mesocentrotus nudus attenuates body weight gain and hepatic lipid accumulation in mice."
  R. Yamamoto, H. Minami, H. Matsusaki, M. Sakashita, N. Morita, O. Nishimiya, N. Tsutsumi, M. Hosokawa, Y. Itabashi, T. Matsui, K. Ura.
  J. Funct. Foods 47, 40 (2018).
• "Carotenoid profiling of a red seaweed Pyropia yezoensis: insights into biosynthetic pathways in the order Bangiales."
  J. Koizumi, N. Takatani, N. Kobayashi, K. Mikami, K. Miyashita, Y. Yamano, A. Wada, T. Maoka, M. Hosokawa.
  Mar. Drugs 16, E426 (2018).
• "Acrolein as a major volatile in the early stages of fish oil TAG oxidation."
  A. Shibata, M. Uemura, M. Hosokawa, K. Miyashita.
  J. Oleo Sci. 67, 515 (2018).
• "Comparison oxidative stability of monoacylglycerol, diacylglycerol, and triacylglycerol containing polyunsaturated fatty acids."
  N.Y.B. Hazahari, M. Hosokawa, K. Miyashita.
  Food Nutr. Sci. 9, 221 (2018).
• "Dietary effect of squalene on lipid metabolism of obese/diabetes KK-Ay mice and wild-type C57BL/6J mice."
  S. Liu, M. Hosokawa, K. Miyashita.
  Food Nutr. Sci. 9, 1498 (2018).

総説・著書

• "Effective prevention of oxidative deterioration of fish oil: Focus on flavor deterioration."
  K. Miyashita, M. Uemura, M. Hosokawa.
  Annu. Rev. Food Sci. Technol. 9, 209 (2018).
• "高度不飽和脂肪酸に対するスフィンゴイド塩基とα-トコフェロールの相乗的抗酸化効果"
  宮下和夫・上村麻梨子・細川雅史.
  オレオサイエンス 18, 317 (2018).

2017年

学術論文

• "Spatial and seasonal variations in the biofunctional lipid substances (fucoxanthin and fucosterol) of the laboratory-grown edible Japanese seaweed (Sargassum horneri Turner) cultured in the open sea."
  M. Terasaki, C. Kawagoe, A. Ito., H. Kumon, B. Narayan, M. Hosokawa, K. Miyashita.
  Saudi J. Biol. Sci. 24, 1475 (2017).
• "Reduction of HbA1c levels by fucoxanthin-enriched akamoku oil possibly involves the thrifty allele of uncoupling protein 1 (UCP1): a randomized controlled trial in normal-weight and obese Japanese adults."
  N. Mikami, M. Hosokawa, K. Miyashita, H. Sohma, Y. M. Ito, Y. Kokai.
  J. Nutr. Sci. 6, e5 (2017).
• "Fatty acid and lipid class composition of the microalga Phaeodactylum tricornutum."
  YH. Yang, L. Du, M. Hosokawa, K. Miyashita, Y. Kokubun, H. Arai, H. Taroda.
  J. Oleo Sci. 66, 363 (2017).
• "Docosapentaenoic acid (22:5n-3) downregulates mRNA expression of pro-inflammatory factors in LPS-activated murine macrophage like RAW264.7 cells."
  Y. Tian, A. Katsuki, D. Romanazzi, M.R. Miller, S.L. Adams, K. Miyashita, M. Hosokawa.
  J. Oleo Sci. 66, 1149 (2017).

総説・著書

• "水産物脂質成分の特徴と機能性"
  細川雅史.
  Food Style21 21, 39 (2017).
• "食品中のカロテノイド類"
  小泉次郎・細川雅史.
  農業および園芸 92, 875 (2017).
• "Fucoxanthin in the management of obesity and its related disorders."
  K. Miyashita, M. Hosokawa.
  J. Funct. Foods 36, 195 (2017).

2016年

学術論文

• "Dietary ALA from spinach enhances liver n-3 fatty acid content to greater extent than linseed oil in mice fed equivalent amounts of ALA."
  M. Kuroe, H. Kamogawa, M. Hosokawa, K. Miyashita.
  Lipids 51, 39 (2016).
• "Does squalene alter the antioxidant potential of astaxanthin and fucoxanthinol? In vitro evidence in RAW 264.7 cells, a murine macrophage."
  S. Ravi Kumar, B. Narayan, Y. Kizawa, M. Hosokawa, K. Miyashita.
  J. Food Sci. Technol. 53, 2139 (2016).
• "Combined effect of astaxanthin and squalene on oxidative stress in vivo."
  S. Ravi Kumar, B. Narayan, Y. Sawada, M. Hosokawa, K. Miyashita.
  Mol. Cell Biochem. 417, 57 (2016).
• "Lipids, fatty acids, and fucoxanthin content from temperate and tropical brown seaweeds."
  E. Susanto, A. S. Fahmi, M. Abe, M. Hosokawa, K. Miyashita.
  Aquatic Procedia 7, 66 (2016).
• "Inhibitory effect of dihydrosphingosine with α-tocopherol on volatile formation during the autoxidation of polyunsaturated triacylglycerols."
  M. Uemura, A. Shibata, M. Hosokawa, A. Iwashima-Suzuki, M. Shiota, K. Miyashita.
  J. Oleo Sci. 65, 713 (2016).
• "The dietary effect of milk sphingomyelin on the lipid metabolism of obese/diabetic KK-Ay mice and wild-type C57BL/6J mice."
  I. Yamauchi, M. Uemura, M. Hosokawa, A. Iwashima-Suzuki, M. Shiota, K. Miyashita.
  Food Funct. 7, 3854 (2016).
• "A protocol for human serum fucoxanthinol quantitation using LC-MS/MS system."
  N. Mikami, Y. Kokai, M. Hosokawa, M. Abe, K. Miyashita, H. Sohma.
  J. Nutr. Med. Diet Care 2, 19 (2016).
• "Squalene modulates fatty acid metabolism: Enhanced EPA/DHA, in obese/diabetic mice (KK-Ay) model."
  S. Ravi Kumar, I. Yamauchi, B. Narayan, A. Katsuki, M. Hosokawa, K. Miyashita.
  Eur. J. Lipid Sci. Technol. 18, 1935 (2016).
• "Bioconversion of docosapentaenoic acid in human cell lines, Caco-2, HepG2, and THP-1."
  Y. Tian, D. Romanazzi, K. Miyashita, M. Hosokawa.
  J. Oleo Sci. 65, 1017 (2016).

総説・著書

• "海藻カロテノイドと不飽和脂肪酸代謝　ワカメの抗肥満効果の機構を探る"
  秋庸裕・細川雅史.
  化学と生物 54, 308 (2016).
• "海洋性カロテノイドの健康機能"
  細川雅史.
  New Food Industry 58, 7 (2016).
• "褐藻由来フコキサンチンの抗肥満・抗糖尿病効果とその機序"
  西川翔・細川雅史・宮下和夫.
  化学と生物 54, 580 (2016).

2015年

学術論文

• "Anti-cancer effects of fucoxanthin and fucoxanthinol on colorectal cancer cell lines and clinical colorectal cancers."
  K. Takahashi, M. Hosokawa, H. Kasajima, K. Hatanaka, K. Kudo, N. Shimoyama, K. Miyashita.
  Oncology Lett. 10, 1463 (2015).
• "Structure of a novel monocyclic carotenoid, 3”-hydroxy-2’-isopentenylsaproxanthin ((3R,2’S)-2′-(3-hydroxy-3-methylbutyl)-3′,4′- didehydro-1′, 2′-dihydro-β, ψ-carotene-3, 1′-diol), from a flavobacterium Gillisia limnaea strain DSM 15749."
  N. Takatani, T. Sawabe, T. Maoka, K. Miyashita, M. Hosokawa.
  Biocatal. Agric. Biotechnol. 4, 174 (2015).
• "Fucoxanthinol, metabolite of fucoxanthin, improves obesity-induced inflammation in adipocyte cells."
  H. Maeda, S. Kanno, M. Kodate, M. Hosokawa, K. Miyashita.
  Mar. Drugs 13, 4799 (2015).
• "Formation of acrolein in the autoxidation of triacylglycerols with different fatty acid compositions."
  A. Shibata, M. Uemura, M. Hosokawa, K. Miyashita.
  J. Am. Oil Chem. Soc. 92, 1661 (2015).

総説・著書

• "ニュートリゲノミクス解析に基づく褐藻カロテノイド，フコキサンチンの栄養機能性"
  宮下和夫・細川雅史.
  生物の科学 遺伝 69, 21 (2015).
• "褐藻カロテノイド，フコキサンチン"
  宮下和夫・細川雅史.
  FFI Journal 220, 101 (2015).

2014年

学術論文

• "Regulation of polyunsaturated fatty acid biosynthesis by seaweed fucoxanthin and its metabolite in cultured hepatocytes."
  T. Aki, M. Yamamoto, T. Toshiaki, K. Tomita, R. Toyoura, K. Iwashita, S. Kawamoto, M. Hosokawa, K. Miyashita, K. Ono.
  Lipids 49, 133 (2014).
• "Identification of a novel carotenoid, 2'-isopentenylsaproxanthin, by Jejuia pallidilutea strain 11shimoA1 and its increased production under alkaline condition."
  N. Takatani, K. Nishida, T. Sawabe, T. Maoka, K. Miyashita, M. Hosokawa.
  Appl. Microbiol. Biotechnol. 98, 6633 (2014).
• "Source-sink manipulation of Camelina sativa L. related to grain yield under stressful environment of Hokkaido, Japan."
  K. Fujita, S. Fujita, T. Fujita, S. Konishi, J. Vollumann, P.K. Mohapatra, M. Hosokawa, M. Kuwahara, H. Saneoka, T. Tadano.
  Soil Sci. Plant Nutr. 60, 156 (2014).
• "Studies on chemical composition of three species of Enteromorpha."
  K. Ganesan, K. Suresh Kumar, P.V. Subba Rao, Y. Tsukui, N. Bhaskarb, M. Hosokawa, K. Miyashita.
  Biomed. Preventive Nutr. 4, 365 (2014).
• "The extracts of Japanese willow tree species are effective for apoptotic desperation or differentiation of acute myeloid leukemia cells."
  K. Fujita, Y. Nomura, M. Sawajiri, P.K. Mohapatra, H.A. El-Shemy, N.T. Nguyen, M. Hosokawa, K. Miyashita, T. Maeda, H. Saneoka, S. Fujita, T. Fujita.
  Pharmacogn Mag. 10, 125 (2014).

総説・著書

• "マリンカロテノイドの炎症性疾患予防作用"
  細川雅史.
  Trace Nutrients Research 31, 80 (2014).

2013年

学術論文

• "Down-regulation of hepatic stearoyl-CoA desaturase 1 expression by fucoxanthin via leptin signaling in diabetic/obese KK-Ay mice."
  F. Beppu, M. Hosokawa, M.J. Yim, T. Shinoda, K. Miyashita.
  Lipids 48, 449 (2013).
• "Bovine lactoferrin reduces visceral fat and liver triglycerides in ICR mice."
  S. Morishita, T. Ono, C. Fujisaki, Y. Ishihara, M Murakoshi, H. Kato, M. Hosokawa, K. Miyashita, K. Sugiyama, H. Nishino.
  J. Oleo Sci. 62, 97 (2013).
• "Seasonal variations of total lipids, fatty acid composition, and fucoxanthin contents of Sargassum horneri (Turner) and Cystoseira hakodatensis (Yendo) from the northern seashore of Japan."
  M. Nomura, H. Kamogawa, E. Susanto, C. Kawagoe, H. Yasui, N. Saga, M. Hosokawa, K. Miyashita.
  J. Appl. Phycol. 25, 1159 (2013).
• "Synergistic antioxidant activity of milk sphingomyeline and its sphingoid base with α-tocopherol on fish oil triacylglycerol."
  J. Shimajiri, M. Shiota, M. Hosokawa, K. Miyashita.
  J. Agric. Food Chem. 61, 7969 (2013).
• "Oxidative stability of lipids rich in EPA and DHA extracted from fermented scallop ovary."
  N. Hamaoka, J. Shimajiri, M. Abe, M. Hosokawa, K. Miyashita.
  J. Food Sci. 78, C1348 (2013).

総説・著書

• "食品と疾病-フコキサンチン"
  宮下和夫・細川雅史（特集企画）.
  Functional Food 6, 220 (2013).
• "Biosynthetic pathway and health beneficial effects of fucoxanthin, an algae-specific xanthophyll in brown seaweeds."
  K. Mikami, M. Hosokawa.
  Int. J. Mol. Sci. 14, 13763 (2013).
• "Chemical and nutritional characteristics of brown seaweed lipids: A review."
  K. Miyashita, N. Mikami, M. Hosokawa.
  J. Functional Foods 5, 1507 (2013).
• "Fucoxanthin, marine carotenoid affecting multiple mechanisms for anti-cancer effect."
  S. Ravi Kumar, M. Hosokawa, K. Miyashita.
  Mar. Drugs 11, 5130 (2013).
• "褐藻カロテノイド，フコキサンチンのUCP1発現亢進作用"
  宮下和夫・細川雅史.
  Bio Industry 30, 31 (2013).

2012年

学術論文

• "Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetic/obese KK-Ay mice."
  S. Nishikawa, M. Hosokawa, K. Miyashita.
  Phytomedicine 19, 389 (2012).
• "Dietary combination of fish oil and taurine decreases fat accumulation and ameliorates blood glucose levels in type 2 diabetic/obese KK-Ay mice."
  N. Mikami, M. Hosokawa, K. Miyashita.
  J. Food Sci. 77, H114 (2012).
• "Effects of dietary fucoxanthin on cholesterol metabolism in diabetic/obese KK-Ay mice."
  F. Beppu, M. Hosokawa, Y. Niwano, K. Miyashita.
  Lipids Health Dis. 11, 112 (2012).
• "Oxidative stability of glyceroglycolipids containing polyunsaturated fatty acids."
  T. Yamaguchi, R. Sugimura, J. Shimajiri, M. Suda, M. Abe, M. Hosokawa, K. Miyashita.
  J. Oleo Sci. 61, 505 (2012).
• "Effect of caffeine and capsaicin on the blood glucose levels of obese/diabetic KK-Ay mice."
  T. Okumura, T. Tsukui, M. Hosokawa, K. Miyashita.
  J. Oleo Sci. 61, 515 (2012).
• "Stability of fucoxanthin in dried Undaria Pinnatifida (Wakame) and baked products (scones) containing wakame powder."
  R. Sugimura, M. Suda, A. Sho, T. Takahashi, T. Sashima, M. Abe, M. Hosokawa, K. Miyashita.
  Food Sci. Technol. Res. 18, 687 (2012).
• "Carotenoid profile of edible Japanese seaweeds: An improved HPLC method for separation of major carotenoids."
  M. Terasaki, B. Narayan, H. Kamogawa, M. Nomura, N. M. Stephen, C. Kawagoe, M. Hosokawa, K. Miyashita.
  J. Aqua. Food Product Technol. 21, 468 (2012).
• "In vivo antioxidant activity of fucoxanthin on obese/diabetes KK-Ay mice."
  S. Iwasaki, M.K.W.A. Airanthi, A. Koide, T. Kaga, S. Nakano, F. Beppu, M. Hosokawa, K. Miyashita.
  Food Nutr. Sci. 3, 1491 (2012).

総説・著書

• "褐藻脂質の多機能性と食品への応用"
  宮下和夫・細川雅史.
  Bio Industry 29, 7 (2012).

2011年

学術論文

• "Synthesis of novel phospholipids that bind phenylalkanols and hydroquinone via phospholipase D-catalyzed transphosphatidylation."
  Y. Yamamoto, H. Kurihara, K. Miyashita, M. Hosokawa.
  New Biotechnol. 28, 1 (2011).
• "Comparative antioxidant activity of edible Japanese brown seaweeds."
  M.K.W.A. Airanthi, M. Hosokawa, K. Miyashita.
  J. Food Sci. 76, C104 (2011).
• "Suppressive effects of amarouciaxanthin A on 3T3-L1 adipocyte differentiation through down-regulation of PPARγ and C/EBPα mRNA expression."
  M.J. Yim, M. Hosokawa, Y. Mizushina, H. Yoshida, Y. Saito, K. Miyashita.
  J. Agric. Food Chem. 59, 1646 (2011).
• "Antiobesity effects of Undaria lipid capsules prepared with scallop phospholipids."
  T. Okada, Y. Mizuno, S. Sibayama, M. Hosokawa, K. Miyashita.
  J. Food Sci. 76, H2 (2011).
• "Effect of brown seaweed lipids on fatty acid composition and lipid hydroperoxide levels of mouse liver."
  M.K.W.A. Airanthi, N. Sasaki, S. Iwasaki, N. Baba, M. Abe, M. Hosokawa, K. Miyashita.
  J. Agric. Food Chem. 59, 4156 (2011).
• "Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines."
  Y. Yasui, M. Hosokawa, N. Mikami, K. Miyashita, T. Tanaka.
  Chem. Biol. Interact. 193, 79 (2011).
• "The effect of milk polar lipids separated from butter serum on the lipid levels in the liver and the plasma of obese-model mouse (KK-Ay)."
  S. Watanabe, T. Takahashi, L. Tanaka, Y. Haruta, M. Shiota, M. Hosokawa, K. Miyashita.
  J. Functional Foods 3, 313 (2011).
• "Nitrocapsanthin and nitrofucoxanthin, respective products of capsanthin and fucoxanthin reaction with peroxynitrite."
  M. Tsuboi, H. Etoh, K. Kato, H. Nakatugawa, H. Kato, Y. Maejima, G. Matsumoto, H. Mori, M. Hosokawa, K. Miyashita, H. Tokuda, N. Suzuki, T. Maoka.
  J. Agric. Food Chem. 59, 10572 (2011).

総説・著書

• "Allenic carotenoid, fucoxanthin, as a novel marine nutraceutical from brown seaweed."
  K. Miyashita, S. Nishikawa, F. Beppu, T. Tsukui, M. Abe, M. Hosokawa.
  J. Sci. Food Agric. 91, 1166 (2011).
• "連載カロテノイド-8- フコキサンチン"
  細川雅史.
  Functional Food 15, 94 (2011).
• "マリンケミカル“フコキサンチン”の抗肥満・抗糖尿病作用"
  細川雅史.
  Materials Integration 24, 6 (2011).
• "Cancer chemopreventive ability of conjugated linolenic acids."
  T. Tanaka, M. Hosokawa, Y. Yasui, R. Ishigamori, K. Miyashita.
  Int. J. Mol. Sci. 12, 7495 (2011).

2010年

学術論文

• "Suppressive effects of the marine carotenoids, fucoxanthin and fucoxanthinol on triglyceride absorption in lymph duct-cannulated rats."
  M. Matsumoto, M. Hosokawa, N. Matsukawa, M. Hagio, A. Shinoki, M. Nishimukai, K. Miyashita, T. Yajima. H. Hara
  Eur. J. Nutr. 49, 243 (2010).
• "Radical scavenging and singlet oxygen quenching activity of extracts from Indian seaweeds"
  N.M. Sachindra, M.K.W.A. Airanthi, M. Hosokawa, K. Miyashita
  J. Food Sci. Technol. 47, 94 (2010).
• "Effects of sea squirt (Halocynthia roretzi) lipids on white adipose tissue weight and blood glucose in diabetic/obese KK-Ay mice"
  N. Mikami, M. Hosokawa, K. Miyashita
  Mol. Med. Reports 3, 449 (2010).
• "Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-Ay mice."
  M. Hosokawa, T. Miyashita, S. Nishikawa, S. Emi, T. Tsukui, F. Beppu, T. Okada, K. Miyashita.
  Arch. Biochem. Biophys. 504, 17 (2010).
• "Purified canola lutein selectively inhibits specific isoforms of mammalian DNA polymerases and reduces inflammatory response."
  S. Horie, C. Okuda, T. Yamashita, K. Watanabe, K. Kuramochi, M. Hosokawa, T. Takeuchi, M. Kakuda, K. Miyashita, F. Sugawara, H. Yoshida, Y. Mizushina.
  Lipids 45, 713 (2010).

総説・著書

• "これからの脂質栄養と機能性食品の開発―海藻の恵みとその利用"
  宮下和夫・細川雅史.
  脂質栄養学 19, 39 (2010).
• "Anti-obesity and anti-diabetic effects of allenic carotenoid, fucoxanthin."
  K. Miyashita, H. Maeda, T. Okada, M. Abe, M. Hosokawa.
  AgroFood Industry Hi-Tech. 21, 24 (2010).